Melanocyte-stimulating hormone receptor

BE0002447ProteinHumansMC1R

G protein-coupled receptor that binds melanocyte-stimulating hormones (alpha, beta, and gamma-MSH) and adrenocorticotropic hormone/ACTH, which are peptide products of the POMC precursor protein (PubMed:11442765, PubMed:11707265, PubMed:1325670, PubMed:1516719, PubMed:8463333). It is acted on by 8 drugs in DrugBank.

Gene name
MC1R
UniProtKB entry
Q01726Swiss-Prot
Cellular location
Cell membrane
Residues / weight
317 residues · 34,705 Da
Also known as
MC1-R · Melanocortin receptor 1 · MSH-R · MSHR

Resolves to

Protein
UniProtQ01726UniProt nameMSHR_HUMAN
Gene
HGNCHGNC:6929NCBI Gene4157GeneCardsMC1R
Pharmacology
IUPHAR/GtoPdb282KEGGhsa:4157
Structure
PDB7F4DPDB7F4FPDB7F4H
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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39+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Melanocyte-stimulating hormone receptor, how selective are they, and which programs against it are still in active trials?

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