Ephrin type-B receptor 4

BE0002453ProteinHumansEPHB4

Receptor tyrosine kinase which binds promiscuously to transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. It is acted on by 13 drugs in DrugBank.

Gene name
EPHB4
UniProtKB entry
P54760Swiss-Prot
Cellular location
Cell membrane
Residues / weight
987 residues · 108,269 Da
Also known as
2.7.10.1 · Hepatoma transmembrane kinase · HTK · MYK1 · TYRO11

Resolves to

Protein
UniProtP54760UniProt nameEPHB4_HUMAN
Gene
HGNCHGNC:3395NCBI Gene2050GeneCardsEPHB4
Pharmacology
IUPHAR/GtoPdb1833KEGGhsa:2050
Structure
PDB2BBAPDB2E7HPDB2HLE
Drugs

What you can answer from here — as of September 07, 2019

13DrugsApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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12GO termsFunction, process and component, as structured annotations
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7Pfam domainsDomain architecture mapped to Pfam families and clans
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54+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ephrin type-B receptor 4, how selective are they, and which programs against it are still in active trials?

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