Uridine phosphorylase 1

BE0002456ProteinHumansUPP1

Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (PubMed:7488099). It is acted on by 3 drugs in DrugBank.

Gene name
UPP1
UniProtKB entry
Q16831Swiss-Prot
Residues / weight
310 residues · 33,934 Da
Also known as
2.4.2.3 · UP · UPase 1 · UrdPase 1

Resolves to

Protein
UniProtQ16831UniProt nameUPP1_HUMAN
Gene
HGNCHGNC:12576NCBI Gene7378GeneCardsUPP1
Pharmacology
KEGGhsa:7378
Structure
PDB3EUEPDB3EUFPDB3NBQ
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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2Metabolic reactionsDrug transformations it catalyses, substrate to product
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Uridine phosphorylase 1, how selective are they, and which programs against it are still in active trials?

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