Uridine phosphorylase 2

BE0002457ProteinHumansUPP2

Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (PubMed:12849978, PubMed:21855639). It is acted on by 2 drugs in DrugBank.

Gene name
UPP2
UniProtKB entry
O95045Swiss-Prot
Residues / weight
317 residues · 35,527 Da
Also known as
2.4.2.3 · UPase 2 · UrdPase 2

Resolves to

Protein
UniProtO95045UniProt nameUPP2_HUMAN
Gene
HGNCHGNC:23061NCBI Gene151531GeneCardsUPP2
Pharmacology
KEGGhsa:151531
Structure
PDB2XRFPDB3P0EPDB3P0F
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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2Metabolic reactionsDrug transformations it catalyses, substrate to product
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Uridine phosphorylase 2, how selective are they, and which programs against it are still in active trials?

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