Non-selective voltage-gated ion channel VDAC1

BE0002468ProteinHumansVDAC1

Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:30061676, PubMed:8420959). It is acted on by 6 drugs in DrugBank.

Gene name
VDAC1
UniProtKB entry
P21796Swiss-Prot
Cellular location
Mitochondrion outer membrane
Residues / weight
283 residues · 30,772 Da
Also known as
hVDAC1 · Outer mitochondrial membrane protein porin 1 · Plasmalemmal porin · Porin 31HL · Porin 31HM

Resolves to

Protein
UniProtP21796UniProt nameVDAC1_HUMAN
Gene
HGNCHGNC:12669NCBI Gene7416GeneCardsVDAC1
Pharmacology
KEGGhsa:7416
Structure
PDB2JK4PDB2K4TPDB5JDP
Drugs

What you can answer from here — as of September 03, 2024

6DrugsApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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44+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Non-selective voltage-gated ion channel VDAC1, how selective are they, and which programs against it are still in active trials?

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