Glial cell line-derived neurotrophic factor

BE0002486ProteinHumansGDNF

Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake (PubMed:8493557). It is acted on by 1 drug in DrugBank.

Gene name
GDNF
UniProtKB entry
P39905Swiss-Prot
Cellular location
Secreted
Residues / weight
211 residues · 23,720 Da
Also known as
Astrocyte-derived trophic factor · ATF · hGDNF

Resolves to

Protein
UniProtP39905UniProt nameGDNF_HUMAN
Gene
HGNCHGNC:4232NCBI Gene2668GeneCardsGDNF
Pharmacology
KEGGhsa:2668
Structure
PDB2V5EPDB3FUBPDB4UX8
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glial cell line-derived neurotrophic factor, how selective are they, and which programs against it are still in active trials?

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