Hypoxanthine-guanine phosphoribosyltransferase
Details
- Name
- Hypoxanthine-guanine phosphoribosyltransferase
- Kind
- protein
- Synonyms
- EC 2.4.2.8
- Gene Name
- HGPRTase
- UniProtKB Entry
- Q27796TrEMBL
- Organism
- Trypanosoma cruzi
- NCBI Taxonomy ID
- 5693
- Amino acid sequence
>lcl|BSEQ0022284|Hypoxanthine-guanine phosphoribosyltransferase MPREYEFAEKILFTEEEIRTRIMEVAKRIADDYKGKGLRPYVNPLVLISVLKGSFMFTAD LCRALSDFNVPVRMEFICVSSYGEGVTSSGQVRMLLDTRHSIEGHHVLIVEDIVDTALTL NYLYHMYFTRRPASLKTVVLLDKREGRRVPFSADYVVANIPNAFVIGYGLDYDDTYRELR DIVVLRPEVYAEREAARQKKQRAIGSADTDRDAKREFHSKY
- Number of residues
- 221
- Molecular Weight
- 25529.02
- Theoretical pI
- 7.61
- GO Classification
- Functionsguanine phosphoribosyltransferase activity / hypoxanthine phosphoribosyltransferase activityProcessespurine ribonucleoside salvageComponentscytoplasm
- General Function
- Hypoxanthine phosphoribosyltransferase activity
- Specific Function
- Not Available
- Pfam Domain Function
- Pribosyltran (PF00156)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm (By similarity)
- Gene sequence
>lcl|BSEQ0004885|666 bp ATGCCACGGGAGTACGAGTTTGCAGAGAAGATTCTTTTCACAGAAGAGGAGATCCGCACC CGCATTATGGAGGTTGCCAAGCGCATTGCGGATGACTACAAGGGAAAGGGTCTGCGCCCT TATGTCAACCCTCTTGTGCTCATATCTGTGCTGAAGGGAAGCTTTATGTTTACTGCTGAC TTGTGCCGTGCACTGAGTGATTTCAACGTGCCGGTGCGAATGGAGTTCATTTGCGTCTCA TCATATGGCGAAGGAGTCACGAGCTCCGGTCAGGTGCGCATGTTGCTTGACACGCGTCAC AGCATTGAGGGGCACCATGTGTTGATTGTGGAGGACATTGTTGACACCGCCCTTACGCTG AATTACTTGTACCACATGTATTTTACACGCAGGCCAGCGAGCTTAAAAACAGTTGTGTTG CTTGACAAGCGTGAGGGGCGACGCGTGCCCTTTTCTGCGGACTACGTTGTGGCGAATATA CCCAACGCCTTTGTGATTGGCTACGGTCTTGATTACGACGACACCTACCGTGAGTTACGC GATATTGTTGTTCTTCGTCCGGAGGTGTATGCGGAGAGGGAGGCGGCGCGGCAGAAGAAG CAGCGGGCCATTGGTAGCGCTGACACCGACAGAGACGCCAAGAGGGAGTTTCATAGCAAG TACTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q27796 UniProtKB Entry Name Q27796_TRYCR GenBank Gene ID L07486 - General References
- Allen TE, Ullman B: Molecular characterization and overexpression of the hypoxanthine-guanine phosphoribosyltransferase gene from Trypanosoma cruzi. Mol Biochem Parasitol. 1994 Jun;65(2):233-45. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 5-O-phosphono-alpha-D-ribofuranosyl diphosphate approved, experimental, investigational unknown target Details Formic acid experimental, investigational unknown target Details Formycin B experimental unknown target Details Inosinic Acid experimental unknown target Details