Cyclopropane mycolic acid synthase MmaA2

BE0002512ProteinMycobacterium tuberculosismmaA2

Catalyzes the conversion of a double bond to a cis cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. It is acted on by 2 drugs in DrugBank.

Gene name
mmaA2
UniProtKB entry
Q79FX6Swiss-Prot
Residues / weight
287 residues · 32,724 Da
Also known as
2.1.1.79 · AdoMet-MT · CFA synthase · CMAS · Cyclopropane-fatty-acyl-phospholipid synthase

Resolves to

Protein
UniProtQ79FX6UniProt nameMMAA2_MYCTU
Gene
NCBI Gene888061
Pharmacology
KEGGmtu:Rv0644c
Structure
PDB1TPY
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cyclopropane mycolic acid synthase MmaA2, how selective are they, and which programs against it are still in active trials?

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