Release factor glutamine methyltransferase

BE0002514ProteinThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)prmC

Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif. It is acted on by 2 drugs in DrugBank.

Gene name
prmC
UniProtKB entry
Q9WYV8Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
282 residues · 31,609 Da
Also known as
2.1.1.297 · N5-glutamine methyltransferase PrmC · Protein-(glutamine-N5) MTase PrmC · Protein-glutamine N-methyltransferase PrmC · RF MTase

Resolves to

Protein
UniProtQ9WYV8UniProt namePRMC_THEMA
Gene
NCBI Gene897528
Pharmacology
KEGGtma:TM0488
Structure
PDB1NV8PDB1NV9PDB1SG9
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Release factor glutamine methyltransferase, and which indications are they being tested in?

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