tRNA (cytidine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase

BE0002518ProteinHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)trmL

Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). It is acted on by 1 drug in DrugBank.

Gene name
trmL
UniProtKB entry
P44868Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
160 residues · 18,401 Da
Also known as
2.1.1.207 · tRNA (cytidine(34)-2'-O)-methyltransferase · tRNA (cytidine/uridine-2'-O-)-methyltransferase · tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmL · yibK

Resolves to

Protein
UniProtP44868UniProt nameTRML_HAEIN
Gene
NCBI Gene949782
Pharmacology
KEGGhin:HI0766
Structure
PDB1J85PDB1MXI
Drugs

What you can answer from here — as of September 08, 2026

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on tRNA (cytidine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase, and which indications are they being tested in?

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