Type II methyltransferase M.PvuII

BE0002519ProteinProteus hauseripvuIIM

A beta subtype methylase, recognizes the double-stranded sequence 5'-CAGCTG-3', methylates C-4 on both strands, and protects the DNA from cleavage by the PvuII endonuclease. It is acted on by 1 drug in DrugBank.

Gene name
pvuIIM
UniProtKB entry
P11409Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
336 residues · 38,365 Da
Also known as
2.1.1.113 · M.PvuII · Modification methylase PvuII · N-4 cytosine-specific methyltransferase PvuII

Resolves to

Protein
UniProtP11409UniProt nameMTP2_PROHU
Structure
PDB1BOO
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
4GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
3+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Type II methyltransferase M.PvuII, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In