DNA adenine methylase

BE0002520ProteinEnterobacteria phage T4DAM

An alpha subtype methylase, recognizes the double-stranded sequence 5'-GATC-3' and methylates A-2. It is acted on by 1 drug in DrugBank.

Gene name
DAM
UniProtKB entry
P04392Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
259 residues · 30,417 Da
Also known as
2.1.1.72 · Deoxyadenosyl-methyltransferase · DNA-(N(6)-adenine)-methyltransferase · M.EcoT4Dam · Orphan methyltransferase M.EcoT4Dam

Resolves to

Protein
UniProtP04392UniProt nameDMA_BPT4
Gene
NCBI Gene1258548
Pharmacology
KEGGvg:1258548
Structure
PDB1Q0SPDB1Q0TPDB1YF3
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which compounds in development act on DNA adenine methylase, and which indications are they being tested in?

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