Type II methyltransferase M.HhaI

BE0002523ProteinHaemophilus parahaemolyticushhaIM

A methylase, recognizes the double-stranded sequence 5'-GCGC-3', methylates C-2 on both strands, and protects the DNA from cleavage by the HhaI endonuclease. It is acted on by 1 drug in DrugBank.

Gene name
hhaIM
UniProtKB entry
P05102Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
327 residues · 36,996 Da
Also known as
2.1.1.37 · Cytosine-specific methyltransferase HhaI · M.HhaI · Modification methylase HhaI

Resolves to

Protein
UniProtP05102UniProt nameMTH1_HAEPH
Structure
PDB10MHPDB1FJXPDB1HMY
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Type II methyltransferase M.HhaI, and which indications are they being tested in?

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