Histone-lysine N-methyltransferase SETD7

BE0002524ProteinHumansSETD7

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3 (PubMed:11779497, PubMed:11850410, PubMed:12540855, PubMed:12588998, PubMed:16141209). It is acted on by 1 drug in DrugBank.

Gene name
SETD7
UniProtKB entry
Q8WTS6Swiss-Prot
Cellular location
Nucleus
Residues / weight
366 residues · 40,721 Da
Also known as
2.1.1.364 · H3-K4-HMTase SETD7 · Histone H3-K4 methyltransferase SETD7 · KIAA1717 · KMT7

Resolves to

Protein
UniProtQ8WTS6UniProt nameSETD7_HUMAN
Gene
HGNCHGNC:30412NCBI Gene80854GeneCardsSETD7
Pharmacology
IUPHAR/GtoPdb2703KEGGhsa:80854
Structure
PDB1H3IPDB1MT6PDB1MUF
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Histone-lysine N-methyltransferase SETD7, and which indications are they being tested in?

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