Uroporphyrinogen-III C-methyltransferase

BE0002528ProteinPseudomonas denitrificanscobA

Catalyzes the two successive C-2 and C-7 methylation reactions involved in the conversion of uroporphyrinogen III to precorrin-2 via the intermediate formation of precorrin-1. It is acted on by 1 drug in DrugBank.

Gene name
cobA
UniProtKB entry
P21631Swiss-Prot
Residues / weight
280 residues · 29,253 Da
Also known as
2.1.1.107 · S-adenosyl-L-methionine:uroporphyrinogen III methyltransferase · SUMT · Urogen III methylase · UROM

Resolves to

Protein
UniProtP21631UniProt nameSUMT_SINSX
Structure
PDB1S4D
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Uroporphyrinogen-III C-methyltransferase, and which indications are they being tested in?

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