2,5-diketo-D-gluconic acid reductase A

BE0002618ProteinCorynebacterium sp. (strain ATCC 31090)dkgA

Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is acted on by 1 drug in DrugBank.

Gene name
dkgA
UniProtKB entry
P06632Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
278 residues · 30,118 Da
Also known as
1.1.1.346 · 2,5-DKG reductase A · AKR5C

Resolves to

Protein
UniProtP06632UniProt nameDKGA_CORSC
Pharmacology
KEGGag:AAA83534
Structure
PDB1A80PDB1HW6PDB1M9H
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 2,5-diketo-D-gluconic acid reductase A, and which indications are they being tested in?

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