Peripheral plasma membrane protein CASK

BE0002641ProteinHumansCASK

Multidomain scaffolding Mg(2+)-independent protein kinase that catalyzes the phosphotransfer from ATP to proteins such as NRXN1, and plays a role in synaptic transmembrane protein anchoring and ion channel trafficking (PubMed:18423203). It is acted on by 2 drugs in DrugBank.

Gene name
CASK
UniProtKB entry
O14936Swiss-Prot
Cellular location
Nucleus
Residues / weight
926 residues · 105,122 Da
Also known as
2.7.11.1 · Calcium/calmodulin-dependent serine protein kinase · hCASK · LIN2 · Protein lin-2 homolog

Resolves to

Protein
UniProtO14936UniProt nameCSKP_HUMAN
Gene
HGNCHGNC:1497NCBI Gene8573GeneCardsCASK
Pharmacology
IUPHAR/GtoPdb1959KEGGhsa:8573
Structure
PDB1KGDPDB1KWAPDB1ZL8
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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21GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Peripheral plasma membrane protein CASK, how selective are they, and which programs against it are still in active trials?

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