Bifunctional adenosylcobalamin biosynthesis protein CobU

BE0002668ProteinSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)cobU

Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. It is acted on by 2 drugs in DrugBank.

Gene name
cobU
UniProtKB entry
Q05599Swiss-Prot
Residues / weight
181 residues · 19,902 Da
Also known as
Adenosylcobinamide kinase · Adenosylcobinamide-phosphate guanylyltransferase

Resolves to

Protein
UniProtQ05599UniProt nameCOBU_SALTY
Gene
NCBI Gene1253539
Pharmacology
KEGGstm:STM2018
Structure
PDB1C9KPDB1CBU
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Bifunctional adenosylcobalamin biosynthesis protein CobU, how selective are they, and which programs against it are still in active trials?

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