1,4-Dihydroxy-2-naphthoyl-CoA synthase

BE0002684ProteinMycobacterium tuberculosismenB

Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA). It is acted on by 2 drugs in DrugBank.

Gene name
menB
UniProtKB entry
P9WNP5Swiss-Prot
Residues / weight
314 residues · 34,689 Da
Also known as
4.1.3.36 · DHNA-CoA synthase

Resolves to

Protein
UniProtP9WNP5UniProt nameMENB_MYCTU
Gene
NCBI Gene887529
Pharmacology
KEGGmtu:Rv0548c
Structure
PDB1Q51PDB1Q52PDB1RJM
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 1,4-Dihydroxy-2-naphthoyl-CoA synthase, and which indications are they being tested in?

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