Biflaviolin synthase CYP158A2

BE0002707ProteinStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)cyp158a2

Catalyzes oxidative C-C coupling reaction to polymerize flaviolin and form highly conjugated pigments which protect the soil bacterium from deleterious effects of UV irradiation (three isomers of biflaviolin and one triflaviolin). It is acted on by 4 drugs in DrugBank.

Gene name
cyp158a2
UniProtKB entry
Q9FCA6Swiss-Prot
Residues / weight
404 residues · 44,354 Da
Also known as
1.14.19.69 · 1.14.21.7 · CYP158A2 · Cytochrome P450 158A2

Resolves to

Protein
UniProtQ9FCA6UniProt nameC1582_STRCO
Gene
NCBI Gene1096630
Pharmacology
KEGGsco:SCO1207
Structure
PDB1S1FPDB1SE6PDB1T93
Drugs

What you can answer from here — as of September 04, 2024

4DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Biflaviolin synthase CYP158A2, and which indications are they being tested in?

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