2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase
Details
- Name
- 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase
- Kind
- protein
- Synonyms
- Not Available
- Gene Name
- cumD
- UniProtKB Entry
- P96965TrEMBL
- Organism
- Pseudomonas fluorescens
- NCBI Taxonomy ID
- 294
- Amino acid sequence
>lcl|BSEQ0022031|2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase MANLEIGKSILAAGVLTNYHDVGEGQPVILIHGSGPGVSAYANWRLTIPALSKFYRVIAP DMVGFGFTDRPENYNYSKDSWVDHIIGIMDALEIEKAHIVGNSFGGGLAIATALRYSERV DRMVLMGAAGTRFDVTEGLNAVWGYTPSIENMRNLLDIFAYDRSLVTDELARLRYEASIQ PGFQESFSSMFPEPRQRWIDALASSDEDIKTLPNETLIIHGREDQVVPLSSSLRLGELID RAQLHVFGRCGHWTQIEQTDRFNRLVVEFFNEANTPKLVGRP
- Number of residues
- 282
- Molecular Weight
- 31489.385
- Theoretical pI
- 5.03
- GO Classification
- Functionshydrolase activity
- General Function
- Not Available
- Specific Function
- hydrolase activity
- Pfam Domain Function
- Abhydrolase_1 (PF00561)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0005375|849 bp ATGGCAAACCTGGAAATAGGTAAAAGTATTTTAGCTGCAGGGGTTCTAACAAACTATCAC GATGTCGGGGAGGGACAGCCTGTGATACTAATTCATGGTTCTGGGCCCGGCGTGAGCGCT TATGCGAATTGGCGACTGACCATTCCTGCTCTGAGCAAGTTTTATCGTGTTATCGCCCCT GATATGGTTGGTTTTGGCTTTACGGATCGACCTGAAAACTATAATTATTCCAAGGATAGT TGGGTTGACCATATAATCGGTATTATGGACGCCCTGGAAATAGAAAAGGCTCACATCGTA GGTAACTCATTCGGTGGGGGGCTGGCGATTGCTACCGCGCTTCGTTATTCGGAGCGCGTT GATCGTATGGTTCTGATGGGGGCGGCCGGTACTCGCTTTGACGTGACAGAGGGCCTGAAC GCGGTGTGGGGTTACACGCCGTCGATAGAAAACATGCGTAATCTCCTCGATATATTCGCT TATGATCGCTCCTTAGTCACCGACGAATTAGCGAGACTTCGATATGAGGCGAGTATTCAG CCAGGATTTCAAGAGTCATTCTCCAGCATGTTTCCTGAGCCGCGCCAACGCTGGATAGAC GCGTTGGCTAGCTCGGATGAAGATATCAAGACTCTTCCCAATGAGACACTGATTATTCAT GGTCGAGAGGATCAGGTTGTTCCTCTATCCAGCAGTCTGCGTCTAGGCGAACTTATCGAC CGGGCGCAGTTGCATGTTTTCGGGCGATGTGGGCACTGGACACAAATTGAGCAGACTGAC CGATTCAATCGTCTTGTGGTCGAGTTTTTTAATGAGGCCAACACACCTAAACTAGTGGGT CGTCCGTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P96965 UniProtKB Entry Name P96965_PSEFL GenBank Gene ID D83955 PDB ID(s) 1IUN, 1IUO, 1IUP, 1UK6, 1UK7, 1UK8, 1UK9, 1UKA, 1UKB, 2D0D - General References
- Fushinobu S, Saku T, Hidaka M, Jun SY, Nojiri H, Yamane H, Shoun H, Omori T, Wakagi T: Crystal structures of a meta-cleavage product hydrolase from Pseudomonas fluorescens IP01 (CumD) complexed with cleavage products. Protein Sci. 2002 Sep;11(9):2184-95. [Article]
- Fushinobu S, Jun SY, Hidaka M, Nojiri H, Yamane H, Shoun H, Omori T, Wakagi T: A series of crystal structures of a meta-cleavage product hydrolase from Pseudomonas fluorescens IP01 (CumD) complexed with various cleavage products. Biosci Biotechnol Biochem. 2005 Mar;69(3):491-8. [Article]
- Jun SY, Fushinobu S, Nojiri H, Omori T, Shoun H, Wakagi T: Improving the catalytic efficiency of a meta-cleavage product hydrolase (CumD) from Pseudomonas fluorescens IP01. Biochim Biophys Acta. 2006 Jul;1764(7):1159-66. Epub 2006 Jun 7. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details N-Valeric Acid experimental unknown target Details Isobutyric acid experimental unknown target Details Butyric Acid experimental, investigational unknown target Details 2-Methylbutanoic Acid experimental unknown target Details Isovaleric Acid experimental unknown target Details Propanoic acid approved, vet_approved unknown target Details Benzoic acid approved, investigational unknown target Details