Peptidoglycan editing factor PgeF

BE0002757ProteinEscherichia coli (strain K12)pgeF

Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine and hypoxanthine (PubMed:31978345). It is acted on by 1 drug in DrugBank.

Gene name
pgeF
UniProtKB entry
P33644Swiss-Prot
Residues / weight
243 residues · 26,339 Da
Also known as
2.4.2.1 · 3.5.-.- · Adenosine deaminase · Adenosine deaminase YfiH · Laccase domain protein YfiH

Resolves to

Protein
UniProtP33644UniProt namePGEF_ECOLI
Gene
NCBI Gene947089
Pharmacology
KEGGecj:JW2575
Structure
PDB1Z9T
Drugs

What you can answer from here — as of June 11, 2026

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Peptidoglycan editing factor PgeF, how selective are they, and which programs against it are still in active trials?

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