Mitogen-activated protein kinase 12

BE0002790ProteinHumansMAPK12

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. It is acted on by 9 drugs in DrugBank.

Gene name
MAPK12
UniProtKB entry
P53778Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
367 residues · 41,940 Da
Also known as
2.7.11.24 · ERK-6 · ERK6 · Extracellular signal-regulated kinase 6 · MAP kinase 12

Resolves to

Protein
UniProtP53778UniProt nameMK12_HUMAN
Gene
HGNCHGNC:6874NCBI Gene6300GeneCardsMAPK12
Pharmacology
IUPHAR/GtoPdb1501KEGGhsa:6300
Structure
PDB1CM8PDB4QUMPDB6UNA
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
13GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
32+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Mitogen-activated protein kinase 12, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In