Probable fumarate reductase Ifc3

BE0002881ProteinShewanella frigidimarina (strain NCIMB 400)ifcA

Flavocytochrome that catalyzes the reduction of fumarate to succinate in vitro (PubMed:10455032). It is acted on by 1 drug in DrugBank.

Gene name
ifcA
UniProtKB entry
Q9Z4P0Swiss-Prot
Cellular location
Periplasm
Residues / weight
588 residues · 62,946 Da
Also known as
1.3.2.- · 1.3.5.4 · Fe(3+)-induced flavocytochrome C3 · Fumarate reductase flavoprotein subunit · Ifc3

Resolves to

Protein
UniProtQ9Z4P0UniProt nameIFCA_SHEFN
Pharmacology
KEGGsfr:Sfri_2586
Structure
PDB1QO8
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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2+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Probable fumarate reductase Ifc3, how selective are they, and which programs against it are still in active trials?

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