4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase

BE0002977ProteinClostridium aminobutyricumabfD

Catalyzes the reversible conversion of 4-hydroxybutyryl-CoA to crotonyl-CoA. It is acted on by 1 drug in DrugBank.

Gene name
abfD
UniProtKB entry
P55792Swiss-Prot
Residues / weight
490 residues · 54,422 Da
Also known as
4-BUDH · 4.2.1.120 · Gamma-aminobutyrate metabolism dehydratase/isomerase

Resolves to

Protein
UniProtP55792UniProt nameHDVD_CLOAM
Pharmacology
KEGGag:CAB60035
Structure
PDB1U8V
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase, how selective are they, and which programs against it are still in active trials?

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