Dehydrogenase/reductase SDR family member 11

BE0003011ProteinHumansDHRS11

Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3beta-hydroxyl metabolites. It is acted on by 1 drug in DrugBank.

Gene name
DHRS11
UniProtKB entry
Q6UWP2Swiss-Prot
Cellular location
Secreted
Residues / weight
260 residues · 28,308 Da
Also known as
17-beta-hydroxysteroid dehydrogenase · 3-beta-hydroxysteroid 3-dehydrogenase · Estradiol 17-beta-dehydrogenase · SDR24C1 · Short-chain dehydrogenase/reductase family 24C member 1

Resolves to

Protein
UniProtQ6UWP2UniProt nameDHR11_HUMAN
Gene
HGNCHGNC:28639NCBI Gene79154GeneCardsDHRS11
Pharmacology
KEGGhsa:79154
Structure
PDB1XG5
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Dehydrogenase/reductase SDR family member 11, and which indications are they being tested in?

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