Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

BE0003094ProteinHumansPAPSS1

Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. It is acted on by 4 drugs in DrugBank.

Gene name
PAPSS1
UniProtKB entry
O43252Swiss-Prot
Residues / weight
624 residues · 70,833 Da
Also known as
ATPSK1 · PAPS synthase 1 · PAPSS · PAPSS 1 · SK 1

Resolves to

Protein
UniProtO43252UniProt namePAPS1_HUMAN
Gene
HGNCHGNC:8603NCBI Gene9061GeneCardsPAPSS1
Pharmacology
KEGGhsa:9061
Structure
PDB1X6VPDB1XJQPDB1XNJ
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1, how selective are they, and which programs against it are still in active trials?

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