2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial

BE0003119ProteinHumansDECR1

Auxiliary enzyme in the beta-oxidation of mono- and polyunsaturated fatty acids (Probable) (PubMed:15531764, PubMed:26474213). It is acted on by 2 drugs in DrugBank.

Gene name
DECR1
UniProtKB entry
Q16698Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
335 residues · 36,067 Da
Also known as
1.3.1.124 · 2,4-dienoyl-CoA reductase [NADPH] · 4-enoyl-CoA reductase [NADPH] · DECR · SDR18C1

Resolves to

Protein
UniProtQ16698UniProt nameDECR_HUMAN
Gene
HGNCHGNC:2753NCBI Gene1666GeneCardsDECR1
Pharmacology
KEGGhsa:1666
Structure
PDB1W6UPDB1W73PDB1W8D
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial, and which indications are they being tested in?

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