High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

BE0003134ProteinHumansPDE9A

Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. It is acted on by 6 drugs in DrugBank.

Gene name
PDE9A
UniProtKB entry
O76083Swiss-Prot
Cellular location
Cell projection, ruffle membrane
Residues / weight
593 residues · 68,492 Da
Also known as
3.1.4.35

Resolves to

Protein
UniProtO76083UniProt namePDE9A_HUMAN
Gene
HGNCHGNC:8795NCBI Gene5152GeneCardsPDE9A
Pharmacology
IUPHAR/GtoPdb1309KEGGhsa:5152
Structure
PDB2HD1PDB2YY2PDB3DY8
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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37+ReferencesStructured and connected to the statements they support
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Which compounds in development act on High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, and which indications are they being tested in?

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