PF-04447943

DB11953InvestigationalSmall molecule

PF-04447943 has been investigated for the treatment of Alzheimer's Disease.

Mechanism: Pharmacologically active on High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Curator reviewed
Formula / weight: C₂₀H₂₅N₇O₂ · 395.4582 g/mol (avg)
Also known as: 4H-pyrazolo(3,4-d)pyrimidin-4-one, 1,5-dihydro-6-((3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl)-1-(tetrahydro-2H-pyran-4-yl)- · 6-((3S,4S)-4-Methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo(3,4-d)pyrimidin-4-one
Code names: PF-04447943

Resolves to

Compound

Structure

InChIKeyIWXUVYOOUMLUTQ-CZUORRHYSA-NSMILESC[C@@H]1CN(CC2=NC=CC=N2)C[C@H]1C1=NC2=C(C=NN2C2CCOCC2)C(=O)N1

Targets

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

7Clinical trialsPhase, status and sponsor resolved per trial

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with PF-04447943, and which of those have an active Phase 3 trial?

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