Serine/threonine-protein phosphatase 5

BE0003160ProteinHumansPPP5C

Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT (PubMed:14734805, PubMed:14764652,... It is acted on by 2 drugs in DrugBank.

Gene name
PPP5C
UniProtKB entry
P53041Swiss-Prot
Cellular location
Nucleus
Residues / weight
499 residues · 56,878 Da
Also known as
3.1.3.16 · PP-T · PP5 · PPP5 · PPT

Resolves to

Protein
UniProtP53041UniProt namePPP5_HUMAN
Gene
HGNCHGNC:9322NCBI Gene5536GeneCardsPPP5C
Pharmacology
KEGGhsa:5536
Structure
PDB1A17PDB1S95PDB1WAO
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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25GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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34+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Serine/threonine-protein phosphatase 5, and which indications are they being tested in?

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