Purine nucleoside phosphorylase

BE0003172ProteinPlasmodium falciparum (isolate 3D7)PNP

As part of the purine salvage pathway, catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (PubMed:14982926, PubMed:16131758, PubMed:18957439, PubMed:19575810, PubMed:24416224,... It is acted on by 2 drugs in DrugBank.

Gene name
PNP
UniProtKB entry
Q8I3X4TrEMBL
Residues / weight
245 residues · 26,858 Da
Also known as
2.4.2.1 · EC 2.4.2.3 · PfPNP · Purine nucleotide phosphorylase, putative · S-methyl-5'-thioinosine phosphorylase

Resolves to

Protein
UniProtQ8I3X4UniProt namePNPH_PLAF7
Gene
NCBI Gene812947
Pharmacology
KEGGpfa:PFE0660c
Structure
PDB1NW4PDB1Q1GPDB1SQ6
Drugs

What you can answer from here — as of May 03, 2025

2DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Purine nucleoside phosphorylase, how selective are they, and which programs against it are still in active trials?

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