Arylsulfatase A

BE0003195ProteinHumansARSA

Lysosomal enzyme that catalyzes the hydrolysis of cerebroside-3-sulfate (N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine) into cerebroside and sulfate, a reaction that requires the activator protein saposin B (PubMed:10751093, PubMed:19224915, PubMed:24294900). It is acted on by 8 drugs in DrugBank.

Gene name
ARSA
UniProtKB entry
P15289Swiss-Prot
Cellular location
Endoplasmic reticulum
Residues / weight
507 residues · 53,588 Da
Also known as
3.1.6.8 · ASA · Cerebroside-sulfatase

Resolves to

Protein
UniProtP15289UniProt nameARSA_HUMAN
Gene
HGNCHGNC:713NCBI Gene410GeneCardsARSA
Pharmacology
KEGGhsa:410
Structure
PDB1AUKPDB1E1ZPDB1E2S
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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71+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Arylsulfatase A, how selective are they, and which programs against it are still in active trials?

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