Micafungin

DB01141ApprovedInvestigationalSmall moleculeEchinocandin Antifungal

Micafungin is an antifungal agent used for the treatment of candidemia, acute disseminated candidiasis, and certain other invasive Candida infections, and for the prophylaxis of Candida infections during stem cell transplantation. It belongs to the antifungal class of compounds known as echinocandins and exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall.

Mechanism: Micafungin inhibits the synthesis of beta-1,3-D-glucan, an essential component of fungal cell walls which is not present in mammalian cells. It does this by inhibiting beta-1,3-D-glucan synthase.
Curator reviewed
Primary indication: Indicated for the treatment of candidemia, acute disseminated candidiasis, and certain other invasive Candida infections, as well as esophageal candidiasis, and prophylaxis of Candida infections in patients undergoing hematopoietic stem cell transplantation.Curator reviewed · 22 structured indications
Formula / weight: C₅₆H₇₁N₉O₂₃S · 1270.274 g/mol (avg)
First approval: Canada, 2022 · United States, 2005
Code names: FK-463
Brand names: Mycamine

Resolves to

Compound

UNIIR10H71BSWGCAS235114-32-6ChEMBLCHEMBL457547ChEBI600520PubChem477468KEGGD02465

Clinical / RWD

RxNorm325887ATCJ02AX05PharmGKBPA164781026

Structure

InChIKeyPIEUQSKUWLMALL-YABMTYFHSA-NSMILES

CCCCCOC1=CC=C(C=C1)C1=CC(=NO1)C1=CC=C(C=C1)C(=O)N[C@H]1C[C@@H](O)[C@@H](O)NC(=O)[C@@H]2[C@@H](O)[C@@H](C)CN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC1=O)[C@@H](C)O)[C@H](O)[C@@H](O)C1=CC(OS(O)(=O)=O)=C(O)C=C1)[C@H](O)CC(N)=O

Targets

A2QLK4fksAP40989GSC2

What you can answer from here — as of September 23, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

576Drug interactionsStructured to mechanism, not free text

59Clinical trialsPhase, status and sponsor resolved per trial

22Structured indicationsCondition, population, route and combination as fields, not prose

1ContraindicationEach with its own population and attribute set

98Marketed productsAcross 9 countries and 38 labellers

1ATC codeIncluding every combination product, plus 14 drug categories

21+ReferencesStructured and connected to the statements they support

Which drugs share a target with Micafungin, and which of those have an active Phase 3 trial?

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