Sialidase-2

BE0003200ProteinHumansNEU2

Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosaccharides (PubMed:14613940, PubMed:22228546). It is acted on by 4 drugs in DrugBank.

Gene name
NEU2
UniProtKB entry
Q9Y3R4Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
380 residues · 42,253 Da
Also known as
3.2.1.18 · Cytosolic sialidase · N-acetyl-alpha-neuraminidase 2 · Neuraminidase-2

Resolves to

Protein
UniProtQ9Y3R4UniProt nameNEUR2_HUMAN
Gene
HGNCHGNC:7759NCBI Gene4759GeneCardsNEU2
Pharmacology
IUPHAR/GtoPdb3258KEGGhsa:4759
Structure
PDB1SNTPDB1SO7PDB1VCU
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sialidase-2, how selective are they, and which programs against it are still in active trials?

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