Oseltamivir is a neuraminidase inhibitor used in the prophylaxis and treatment of influenza. Oseltamivir exerts its antiviral activity by inhibiting the activity of the viral neuraminidase enzyme found on the surface of the virus, which prevents budding from the host cell, viral replication, and infectivity.
- Mechanism
- Curator reviewed · 6 references
Oseltamivir phosphate is a pro-drug of the active metabolite (oseltamivir carboxylate) which is a potent and selective inhibitor of influenza virus neuraminidase enzymes, which are glycoproteins found on the virion surface. Viral neuraminidase enzyme activity is important for viral entry into uninfected cells, for the release of recently formed virus particles from infected cells, and for the further spread of the infectious virus in the body. Oseltamivir activity reduces viral shedding and infectivity.
Oseltamivir is effective agaisnt viral neuraminidases of influenza A (including pandemic H1N1) and influenza B.
- Primary indication
- According to FDA prescribing information, oseltamivir is indicated for the treatment of acute, uncomplicated illness due to influenza A and B infection in patients 2 weeks of age and older who have been symptomatic for...Curator reviewed · 10 structured indications
- Formula / weight
- C16H28N2O4 · 312.4045 g/mol (avg)
- First approval
- Canada, 1999 · United States, 1999 · European Union, 2016
- Code names
- GS-4071 ETHYL ESTER · GS-4104 · HSDB 7433 · RO-64-0796
- Brand names
Resolves to
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Which drugs share a target with Oseltamivir, and which of those have an active Phase 3 trial?
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