Transketolase 1

BE0003276ProteinEscherichia coli (strain K12)tktA

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. It is acted on by 2 drugs in DrugBank.

Gene name
tktA
UniProtKB entry
P27302Swiss-Prot
Residues / weight
663 residues · 72,211 Da
Also known as
2.2.1.1 · TK 1 · tkt

Resolves to

Protein
UniProtP27302UniProt nameTKT1_ECOLI
Gene
NCBI Gene947420
Pharmacology
KEGGecj:JW5478
Structure
PDB1QGDPDB2R5NPDB2R8O
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Transketolase 1, how selective are they, and which programs against it are still in active trials?

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