ADP-ribosylation factor 4
Details
- Name
- ADP-ribosylation factor 4
- Kind
- protein
- Synonyms
- ARF2
- Gene Name
- ARF4
- UniProtKB Entry
- P18085Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0020663|ADP-ribosylation factor 4 MGLTISSLFSRLFGKKQMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKN ICFTVWDVGGQDRIRPLWKHYFQNTQGLIFVVDSNDRERIQEVADELQKMLLVDELRDAV LLLFANKQDLPNAMAISEMTDKLGLQSLRNRTWYVQATCATQGTGLYEGLDWLSNELSKR
- Number of residues
- 180
- Molecular Weight
- 20510.615
- Theoretical pI
- 7.25
- GO Classification
- Functionsguanyl-nucleotide exchange factor activity / NAD+-protein-arginine ADP-ribosyltransferase activity / phospholipase D activator activityProcessescilium assembly / endoplasmic reticulum to Golgi vesicle-mediated transport / intracellular protein transport / positive regulation of transcription by RNA polymerase II / regulation of cilium assembly / regulation of postsynapse organization / retrograde vesicle-mediated transport, Golgi to endoplasmic reticulumComponentsglutamatergic synapse / Golgi membrane / plasma membrane
- General Function
- GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879)
- Specific Function
- epidermal growth factor receptor binding
- Pfam Domain Function
- Arf (PF00025)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Golgi apparatus
- Gene sequence
>lcl|BSEQ0020664|ADP-ribosylation factor 4 (ARF4) ATGGGCCTCACTATCTCCTCCCTCTTCTCCCGACTATTTGGCAAGAAGCAGATGCGCATT TTGATGGTTGGATTGGATGCTGCTGGCAAGACAACCATTCTGTATAAACTGAAGTTAGGG GAGATAGTCACCACCATTCCTACCATTGGTTTTAATGTGGAAACAGTAGAATATAAGAAC ATTTGTTTCACAGTATGGGATGTTGGTGGTCAAGATAGAATTAGGCCTCTCTGGAAGCAT TACTTCCAGAATACCCAGGGTCTTATTTTTGTGGTAGATAGCAACGATCGTGAAAGAATT CAGGAAGTAGCAGATGAGCTGCAGAAAATGCTTCTGGTAGATGAATTGAGAGATGCAGTG CTGCTACTTTTTGCAAACAAACAGGATTTGCCAAATGCTATGGCCATCAGTGAAATGACA GATAAACTAGGGCTTCAGTCTCTTCGTAACAGAACATGGTATGTTCAAGCCACTTGTGCA ACACAAGGAACTGGTCTGTATGAAGGACTTGACTGGCTGTCAAATGAGCTTTCAAAACGT TAA
- Chromosome Location
- 3
- Locus
- 3p14.3
- External Identifiers
Resource Link UniProtKB ID P18085 UniProtKB Entry Name ARF4_HUMAN GenBank Gene ID M36341 GeneCard ID ARF4 GenAtlas ID ARF4 HGNC ID HGNC:655 PDB ID(s) 1Z6X KEGG ID hsa:378 NCBI Gene ID 378 - General References
- Monaco L, Murtagh JJ, Newman KB, Tsai SC, Moss J, Vaughan M: Selective amplification of an mRNA and related pseudogene for a human ADP-ribosylation factor, a guanine nucleotide-dependent protein activator of cholera toxin. Proc Natl Acad Sci U S A. 1990 Mar;87(6):2206-10. [Article]
- Kahn RA, Kern FG, Clark J, Gelmann EP, Rulka C: Human ADP-ribosylation factors. A functionally conserved family of GTP-binding proteins. J Biol Chem. 1991 Feb 5;266(4):2606-14. [Article]
- Lebeda RA, Haun RS: Cloning and characterization of the human ADP-ribosylation factor 4 gene. Gene. 1999 Sep 3;237(1):209-14. [Article]
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- Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Guanosine-5'-Diphosphate experimental unknown target Details