GDP-mannose 4,6-dehydratase

Details

Name
GDP-mannose 4,6-dehydratase
Kind
protein
Synonyms
  • 4.2.1.47
  • gca
  • GDP-D-mannose dehydratase
Gene Name
gmd
UniProtKB Entry
Q51366Swiss-Prot
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
NCBI Taxonomy ID
208964
Amino acid sequence
>lcl|BSEQ0012290|GDP-mannose 4,6-dehydratase
MTRSALVTGITGQDGAYLAKLLLEKGYRVHGLVARRSSDTRWRLRELGIEGDIQYEDGDM
ADACSVQRAVIKAQPQEVYNLAAQSFVGASWNQPVTTGVVDGLGVTHLLEAIRQFSPETR
FYQASTSEMFGLIQAERQDENTPFYPRSPYGVAKLYGHWITVNYRESFGLHASSGILFNH
ESPLRGIEFVTRKVTDAVARIKLGKQQELRLGNVDAKRDWGFAGDYVEAMWLMLQQDKAD
DYVVATGVTTTVRDMCQIAFEHVGLDYRDFLKIDPAFFRPAEVDVLLGNPAKAQRVLGWK
PRTSLDELIRMMVEADLRRVSRE
Number of residues
323
Molecular Weight
36399.08
Theoretical pI
6.53
GO Classification
Functions
GDP-mannose 4,6-dehydratase activity / NADP+ binding
Processes
GDP-mannose metabolic process / lipopolysaccharide biosynthetic process
General Function
Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
Specific Function
GDP-mannose 4,6-dehydratase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0012291|GDP-mannose 4,6-dehydratase (gmd)
ATGACAAGAAGTGCACTGGTAACTGGGATCACCGGTCAGGACGGAGCGTACCTGGCCAAG
CTGCTGCTGGAGAAGGGCTACCGGGTCCACGGCCTGGTGGCGCGGCGCAGCAGCGACACG
CGCTGGCGCCTGCGCGAACTGGGGATCGAAGGCGATATCCAGTACGAGGACGGCGACATG
GCCGATGCCTGTTCGGTGCAGCGCGCGGTGATCAAGGCGCAGCCGCAGGAGGTCTACAAC
CTGGCGGCACAGAGCTTCGTCGGGGCCTCCTGGAACCAGCCGGTGACCACCGGCGTCGTC
GACGGCCTGGGCGTGACCCACCTGCTCGAGGCGATCCGCCAGTTCAGCCCGGAAACGCGC
TTCTACCAGGCTTCCACCAGCGAGATGTTCGGCCTGATCCAGGCCGAGCGCCAGGACGAG
AACACGCCGTTCTACCCGCGCAGCCCCTACGGCGTGGCCAAGCTCTATGGCCACTGGATC
ACCGTCAACTATCGCGAGAGCTTCGGCCTGCACGCCTCCAGCGGCATCCTGTTCAACCAC
GAATCGCCGCTGCGCGGCATCGAGTTCGTCACGCGCAAGGTTACCGACGCGGTGGCCCGC
ATCAAGCTCGGCAAGCAGCAGGAATTGCGCCTGGGCAACGTCGACGCCAAGCGCGACTGG
GGCTTTGCCGGGGACTACGTCGAAGCCATGTGGCTGATGTTGCAGCAGGACAAGGCCGAC
GACTACGTGGTGGCCACCGGTGTCACTACCACCGTGCGCGACATGTGCCAGATCGCTTTC
GAGCATGTGGGCCTGGACTACCGCGACTTCCTCAAGATCGACCCGGCGTTCTTCCGGCCC
GCCGAGGTCGACGTGCTGCTGGGTAATCCGGCCAAGGCCCAGCGTGTGCTCGGCTGGAAG
CCCAGGACCAGCCTGGACGAGCTGATCCGGATGATGGTCGAGGCGGACCTGCGACGCGTT
TCCCGGGAGTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ51366
UniProtKB Entry NameGM4D_PSEAE
GenBank Gene IDU18320
PDB ID(s)1RPN
KEGG IDpae:PA5453
NCBI Gene ID883089
General References
  1. Currie HL, Lightfoot J, Lam JS: Prevalence of gca, a gene involved in synthesis of A-band common antigen polysaccharide in Pseudomonas aeruginosa. Clin Diagn Lab Immunol. 1995 Sep;2(5):554-62. [Article]
  2. Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. [Article]
  3. Webb NA, Mulichak AM, Lam JS, Rocchetta HL, Garavito RM: Crystal structure of a tetrameric GDP-D-mannose 4,6-dehydratase from a bacterial GDP-D-rhamnose biosynthetic pathway. Protein Sci. 2004 Feb;13(2):529-39. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Guanosine-5'-DiphosphateexperimentalunknowntargetDetails