GTP 3',8-cyclase

BE0003313ProteinStaphylococcus aureus (strain MW2)moaA

Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate. It is acted on by 1 drug in DrugBank.

Gene name
moaA
UniProtKB entry
P65389Swiss-Prot
Residues / weight
340 residues · 39,078 Da
Also known as
4.1.99.18 · 4.1.99.22 · Cyclic pyranopterin monophosphate synthase · Molybdenum cofactor biosynthesis protein A

Resolves to

Protein
UniProtP65389UniProt nameMOAA_STAAW
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on GTP 3',8-cyclase, and which indications are they being tested in?

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