Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

BE0003323ProteinHumansPDE1B

Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:15260978, PubMed:8855339, PubMed:9419816). It is acted on by 5 drugs in DrugBank.

Gene name
PDE1B
UniProtKB entry
Q01064Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
536 residues · 61,379 Da
Also known as
3.1.4.17 · 63 kDa Cam-PDE · Cam-PDE 1B · PDES1B

Resolves to

Protein
UniProtQ01064UniProt namePDE1B_HUMAN
Gene
HGNCHGNC:8775NCBI Gene5153GeneCardsPDE1B
Pharmacology
IUPHAR/GtoPdb1295KEGGhsa:5153
Structure
PDB1TAZPDB4NPVPDB4NPW
Drugs

What you can answer from here — as of September 03, 2024

5DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, how selective are they, and which programs against it are still in active trials?

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