Hydroxymethylglutaryl-CoA lyase, mitochondrial

BE0003332ProteinHumansHMGCL

Mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. It is acted on by 1 drug in DrugBank.

Gene name
HMGCL
UniProtKB entry
P35914Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
325 residues · 34,360 Da
Also known as
3-hydroxy-3-methylglutarate-CoA lyase · 4.1.3.4 · HL · HMG-CoA lyase

Resolves to

Protein
UniProtP35914UniProt nameHMGCL_HUMAN
Gene
HGNCHGNC:5005NCBI Gene3155GeneCardsHMGCL
Pharmacology
KEGGhsa:3155
Structure
PDB2CW6PDB3MP3PDB3MP4
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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28+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Hydroxymethylglutaryl-CoA lyase, mitochondrial, and which indications are they being tested in?

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