Wee1-like protein kinase

BE0003335ProteinHumansWEE1

Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'... It is acted on by 9 drugs in DrugBank.

Gene name
WEE1
UniProtKB entry
P30291Swiss-Prot
Cellular location
Nucleus
Residues / weight
646 residues · 71,597 Da
Also known as
2.7.10.2 · Wee1A kinase · WEE1hu

Resolves to

Protein
UniProtP30291UniProt nameWEE1_HUMAN
Gene
HGNCHGNC:12761NCBI Gene7465GeneCardsWEE1
Pharmacology
IUPHAR/GtoPdb2278KEGGhsa:7465
Structure
PDB1X8BPDB2IN6PDB2IO6
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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37+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Wee1-like protein kinase, how selective are they, and which programs against it are still in active trials?

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