Thymidine kinase

Details

Name
Thymidine kinase
Kind
protein
Synonyms
  • 2.7.1.21
Gene Name
Not Available
UniProtKB Entry
P0C0E6Swiss-Prot
Organism
HHV-3
NCBI Taxonomy ID
341980
Amino acid sequence
>lcl|BSEQ0012353|Thymidine kinase
MSTDKTDVKMGVLRIYLDGAYGIGKTTAAEEFLHHFAITPNRILLIGEPLSYWRNLAGED
AICGIYGTQTRRLNGDVSPEDAQRLTAHFQSLFCSPHAIMHAKISALMDTSTSDLVQVNK
EPYKIMLSDRHPIASTICFPLSRYLVGDMSPAALPGLLFTLPAEPPGTNLVVCTVSLPSH
LSRVSKRARPGETVNLPFVMVLRNVYIMLINTIIFLKTNNWHAGWNTLSFCNDVFKQKLQ
KSECIKLREVPGIEDTLFAVLKLPELCGEFGNILPLWAWGMETLSNCLRSMSPFVLSLEQ
TPQHAAQELKTLLPQMTPANMSSGAWNILKELVNAVQDNTS
Number of residues
341
Molecular Weight
37842.57
Theoretical pI
7.22
GO Classification
Functions
ATP binding / thymidine kinase activity
Processes
DNA biosynthetic process / TMP biosynthetic process
General Function
Catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis. The dTMP serves as a substrate for DNA polymerase during viral DNA replication. Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors.
Specific Function
ATP binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0006565|1026 bp
ATGTCAACGGATAAAACCGATGTAAAAATGGGCGTTTTGCGTATTTATTTGGACGGGGCG
TATGGAATTGGAAAAACAACCGCCGCCGAAGAATTTTTACACCACTTTGCAATAACACCA
AACCGGATCTTACTCATTGGGGAGCCCCTGTCGTATTGGCGTAACCTTGCAGGGGAGGAC
GCTATTTGCGGAATTTACGGAACACAAACTCGCCGTCTTAATGGAGACGTTTCGCCTGAA
GACGCACAACGCCTCACGGCTCATTTTCAGAGCCTGTTCTGTTCTCCGCATGCAATTATG
CATGCGAAAATCTCGGCATTGATGGACACAAGTACATCGGATCTCGTACAAGTAAATAAG
GAGCCGTATAAAATTATGTTATCCGACCGACACCCAATCGCCTCAACTATATGTTTTCCC
TTGTCCAGATACTTAGTGGGAGATATGTCCCCAGCGGCGCTTCCTGGGTTATTGTTTACG
CTTCCCGCTGAACCCCCCGGGACCAACTTGGTAGTTTGTACCGTTTCACTCCCCAGTCAT
TTATCCAGAGTAAGCAAACGGGCCAGACCGGGAGAAACGGTTAATCTGCCGTTTGTTATG
GTTCTGAGAAATGTATATATAATGCTTATTAATACAATTATATTTCTTAAAACTAACAAC
TGGCACGCGGGCTGGAACACACTGTCATTTTGTAATGATGTATTTAAACAGAAATTACAA
AAATCCGAGTGTATAAAACTACGCGAAGTACCTGGGATTGAAGACACGTTATTCGCCGTN
CTTAAACTTCCGGAGCTTTGCGGAGAGTTTGGAAATATTCTGCCGTTATGGGCATGGGGA
ATGGAGACCCTTTCAAACTGCTTACGAAGCATGTCTCCGTTCGTATTATCGTTAGAACAG
ACACCCCAGCATGCGGCACAAGAACTAAAAACTCTGCTACCCCAGATGACCCCGGCAAAC
ATGTCCTCCGGTGCATGGAATATATTGAAAGAGCTTGTTAATGCCGTTCAGGACAACACT
TCCTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP0C0E6
UniProtKB Entry NameKITH_VZVO
GenBank Gene IDM36160
PDB ID(s)1OSN
General References
  1. Sawyer MH, Inchauspe G, Biron KK, Waters DJ, Straus SE, Ostrove JM: Molecular analysis of the pyrimidine deoxyribonucleoside kinase gene of wild-type and acyclovir-resistant strains of varicella-zoster virus. J Gen Virol. 1988 Oct;69 ( Pt 10):2585-93. [Article]
  2. Mori H, Shiraki K, Kato T, Hayakawa Y, Yamanishi K, Takahashi M: Molecular analysis of the thymidine kinase gene of thymidine kinase-deficient mutants of varicella-zoster virus. Intervirology. 1988;29(6):301-10. [Article]
  3. Lacey SF, Suzutani T, Powell KL, Purifoy DJ, Honess RW: Analysis of mutations in the thymidine kinase genes of drug-resistant varicella-zoster virus populations using the polymerase chain reaction. J Gen Virol. 1991 Mar;72 ( Pt 3):623-30. [Article]
  4. Gomi Y, Sunamachi H, Mori Y, Nagaike K, Takahashi M, Yamanishi K: Comparison of the complete DNA sequences of the Oka varicella vaccine and its parental virus. J Virol. 2002 Nov;76(22):11447-59. [Article]
  5. Tillieux SL, Halsey WS, Thomas ES, Voycik JJ, Sathe GM, Vassilev V: Complete DNA sequences of two oka strain varicella-zoster virus genomes. J Virol. 2008 Nov;82(22):11023-44. doi: 10.1128/JVI.00777-08. Epub 2008 Sep 10. [Article]
  6. Bird LE, Ren J, Wright A, Leslie KD, Degreve B, Balzarini J, Stammers DK: Crystal structure of varicella zoster virus thymidine kinase. J Biol Chem. 2003 Jul 4;278(27):24680-7. Epub 2003 Apr 9. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Brivudine monophosphateexperimentalunknowntargetDetails