Growth hormone secretagogue receptor type 1

BE0003383ProteinHumansGHSR

G protein-coupled receptor specific to ghrelin, an appetite-regulating peptide hormone commonly found in stomach (PubMed:35027551, PubMed:39833471). It is acted on by 16 drugs in DrugBank.

Gene name
GHSR
UniProtKB entry
Q92847Swiss-Prot
Cellular location
Cell membrane
Residues / weight
366 residues · 41,328 Da
Also known as
GH-releasing peptide receptor · Ghrelin receptor · GHRP · GHS-R

Resolves to

Protein
UniProtQ92847UniProt nameGHSR_HUMAN
Gene
HGNCHGNC:4267NCBI Gene2693GeneCardsGHSR
Pharmacology
IUPHAR/GtoPdb246KEGGhsa:2693
Structure
PDB6KO5PDB7F83PDB7F9Y
Drugs

What you can answer from here — as of September 07, 2019

16DrugsApproved to experimental, with action, bond type and pharmacological action
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40GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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63+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Growth hormone secretagogue receptor type 1, how selective are they, and which programs against it are still in active trials?

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