Thioredoxin reductase 2, mitochondrial

BE0003388ProteinHumansTXNRD2

Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (PubMed:24601690). It is acted on by 3 drugs in DrugBank.

Gene name
TXNRD2
UniProtKB entry
Q9NNW7Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
524 residues · 56,506 Da
Also known as
1.8.1.9 · KIAA1652 · Selenoprotein Z · SelZ · Thioredoxin reductase TR3

Resolves to

Protein
UniProtQ9NNW7UniProt nameTRXR2_HUMAN
Gene
HGNCHGNC:18155NCBI Gene10587GeneCardsTXNRD2
Pharmacology
KEGGhsa:10587
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Thioredoxin reductase 2, mitochondrial, and which indications are they being tested in?

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