Carboxypeptidase B2

BE0003407ProteinHumansCPB2

Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. It is acted on by 5 drugs in DrugBank.

Gene name
CPB2
UniProtKB entry
Q96IY4Swiss-Prot
Cellular location
Secreted
Residues / weight
423 residues · 48,424 Da
Also known as
3.4.17.20 · Carboxypeptidase U · CPU · pCPB · Plasma carboxypeptidase B

Resolves to

Protein
UniProtQ96IY4UniProt nameCBPB2_HUMAN
Gene
HGNCHGNC:2300NCBI Gene1361GeneCardsCPB2
Pharmacology
IUPHAR/GtoPdb1594KEGGhsa:1361
Structure
PDB3D66PDB3D67PDB3D68
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Carboxypeptidase B2, how selective are they, and which programs against it are still in active trials?

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