Cathepsin K

BE0003417ProteinHumansCTSK

Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. It is acted on by 25 drugs in DrugBank.

Gene name
CTSK
UniProtKB entry
P43235Swiss-Prot
Cellular location
Lysosome
Residues / weight
329 residues · 36,966 Da
Also known as
3.4.22.38 · Cathepsin O · Cathepsin O2 · Cathepsin X · CTSO

Resolves to

Protein
UniProtP43235UniProt nameCATK_HUMAN
Gene
HGNCHGNC:2536NCBI Gene1513GeneCardsCTSK
Pharmacology
IUPHAR/GtoPdb2350KEGGhsa:1513
Structure
PDB1ATKPDB1AU0PDB1AU2
Drugs

What you can answer from here — as of September 07, 2019

25DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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64+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Cathepsin K, and which indications are they being tested in?

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