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ONO-5334

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Data Packages
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Identification

Generic Name
ONO-5334
DrugBank Accession Number
DB19206
Background

ONO-5334 is under investigation in clinical trial NCT00532337 (Controlled Study of ONO-5334 in Postmenopausal Women With Osteopenia or Osteoporosis).

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 438.59
Monoisotopic: 438.230076765
Chemical Formula
C21H34N4O4S
Synonyms
  • N-((1S)-3-((2Z)-2-((4R)-3,4-DIMETHYL-1,3-THIAZOLIDIN-2-YLIDENE)HYDRAZINO)-2,3-DIOXO-1-(TETRAHYDRO-2H-PYRAN-4YL)PROPYL)CYCLOHEPTANECARBOXAMIDE
External IDs
  • ONO 5334
  • ONO-5334
  • ONO5334
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
ACathepsin K
inhibitor
Humans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
9TDN93L9FN
CAS number
620614-15-5
InChI Key
BTZCSXIUAFVRTE-CHGLIHOBSA-N
InChI
InChI=1S/C21H34N4O4S/c1-14-13-30-21(25(14)2)24-23-20(28)18(26)17(15-9-11-29-12-10-15)22-19(27)16-7-5-3-4-6-8-16/h14-17H,3-13H2,1-2H3,(H,22,27)(H,23,28)/b24-21-/t14-,17+/m1/s1
IUPAC Name
SMILES
C[C@@H]1CS\C(=N/NC(=O)C(=O)[C@@H](NC(=O)C2CCCCCC2)C2CCOCC2)N1C

References

General References
Not Available
ChemSpider
9757748
ChEMBL
CHEMBL4303672
ZINC
ZINC000035861659

Clinical Trials

Clinical Trials
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PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns
Unlock 175K+ rows when you subscribe.View sample data
2CompletedTreatmentOsteopenia (Disorder) / Osteoporosis1somestatusstop reasonjust information to hide
1, 2CompletedTreatmentHealthy, Postmenopausal Women1somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Targets

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Details1. Cathepsin K
Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Inhibitor
General Function
Proteoglycan binding
Specific Function
Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an i...
Gene Name
CTSK
Uniprot ID
P43235
Uniprot Name
Cathepsin K
Molecular Weight
36965.82 Da
References
  1. Zhou Y, Zhang Y, Zhao D, Yu X, Shen X, Zhou Y, Wang S, Qiu Y, Chen Y, Zhu F: TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751. [Article]

Drug created at July 08, 2024 21:56 / Updated at August 27, 2024 19:17