Heat shock protein beta-1

BE0003432ProteinHumansHSPB1

Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). It is acted on by 3 drugs in DrugBank.

Gene name
HSPB1
UniProtKB entry
P04792Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
205 residues · 22,782 Da
Also known as
28 kDa heat shock protein · Estrogen-regulated 24 kDa protein · Heat shock 27 kDa protein · Heat shock protein family B member 1 · HSP 27

Resolves to

Protein
UniProtP04792UniProt nameHSPB1_HUMAN
Gene
HGNCHGNC:5246NCBI Gene3315GeneCardsHSPB1
Pharmacology
KEGGhsa:3315
Structure
PDB2N3JPDB3Q9PPDB3Q9Q
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
1Clinical trialTrials of drugs acting on it, by phase and status
Sign in
28GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
39+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Heat shock protein beta-1, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In